MIIP and familial pancreatic carcinoma: Niu et al. (Bae et al., 2015) examined the reciprocal loop of hypoxia-inducible factor 1α (HIF-1α)/miR-646/MIIP in pancreatic cancer and observed that MIIP could suppress the deacetylase ability of HDAC6, which promoted HIF-1α acetylation and degradation, leading to decreased HIF-1α accumulation.