MAPK8 and hepatocellular carcinoma: Bae et al. (2015) reported that miR-221 suppresses HDAC6; moreover, this suppression was induced by JNK/c-Jun signaling in HCC without effecting normal hepatic cells. Furthermore, miR-221 was independently regulated by cytokine-induced NF-κBp65 upon suppressed HDAC6 expression in HCC cells. Li et al. (2021) observed that long noncoding RNA LINC00624 could disrupt the formation of the HDAC6-TRIM28-ZNF354C transcriptional corepressor complex in HCC, followed by the dissociation of the complex from the promoter of CHD1L and BCL9, which eventually clears the transcription inhibition.