Bae et al. (2015) reported that miR-221 suppresses HDAC6; moreover, this suppression was induced by JNK/c-Jun signaling in HCC without effecting normal hepatic cells. Furthermore, miR-221 was independently regulated by cytokine-induced NF-κBp65 upon suppressed HDAC6 expression in HCC cells. Li et al. (2021) observed that long noncoding RNA LINC00624 could disrupt the formation of the HDAC6-TRIM28-ZNF354C transcriptional corepressor complex in HCC, followed by the dissociation of the complex from the promoter of CHD1L and BCL9, which eventually clears the transcription inhibition. The gene discussed is TRIM28; the disease is hepatocellular carcinoma.