While the detailed mechanism of microbiota-mediated regulation of ILC2s migration from the gut to the lungs remains to be determined, it has been recently demonstrated that IL-33/CXCL16 axis regulates migration of nILC2 to the lungs, whereas IL-25/CCL25 axis facilitates migration of iILC2s to the intestine during infection (Pu et al., 2021). This evidence concerns the gene IL33 and infection.