Rats selected for 16S rRNA sequencing and metabolomics analysis showed statistical significances in blood lipid levels (TG, TC, HDL, LDL, Table S2), liver (ALT, AST) and kidney (Cr, BUN) function-related indicators (Table S3), FBG (Figure S3A), AUC of OGTT (Figure S3B, C), FINS and HOMA-IR (Table S4) between Control and T2DM groups and between T2DM and PDJQ high-dose groups. Here, GPT is linked to type 2 diabetes mellitus.