MAPKAPK3 and central nervous system cancer: In addition, we performed a subgroup survival analysis of OS with TCGA dataset, and we found that high expression of MK3 was associated with poor prognosis in WHO grade G3, non-codel 1p/19q codeletion, age less than or equal to 60 years, age greater than 60 years, and histological type astrocytoma subgroup of glioma (Figures 3G–O).