However, the glioma, especially GBM, still remains incurable with poor prognosis, which imposes enormous pressure on society, although some clinically relevant epigenetic biomarkers such as IDH status, O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status, histone code, and chromatin organization have been used for classification of glioma and treatment decisions (9). Here, MGMT is linked to central nervous system cancer.