Knockout of both the mutated and wild type IDH1 via CRISPR–Cas9 from chondrosarcoma cell lines impaired anchorage-independent cell growth and migration with downregulation of integrins, which implicated mutant IDH1 in chondrosarcoma in the epithelial-to-mesenchymal transition with reduced growth rates in vivo and this phenotype was not rescued with restoration experiments with wild type IDH1 (12). This evidence concerns the gene IDH1 and chondrosarcoma.