This metabolomic profile of IDH mutated chondrosarcoma is consistent with increased glycolysis, anaplerotic flux into the TCA cycle and fatty acid oxidation (21) and is consistent with other studies that have revealed that there is HIF activation, high rates of glutaminolysis and lipid metabolism in chondrosarcomas (7, 15, 22, 23). This evidence concerns the gene IDH2 and chondrosarcoma.