VEGF-A expression was induced by adiponectin through the utilization of the adiponectin receptor, PI3K, AKT, mTOR and HIF-1a pathways 7,59. Pretreatment of chondrosarcoma cells with PI3K, AKT or mTOR inhibitors abolished the adiponectin effect on VEGF-A. Here, AKT1 is linked to chondrosarcoma.