MCT4 is involved in the release of monocarboxylates from cells, is regulated by catabolic transcription factors such as hypoxia inducible factor 1 alpha (HIF1A) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and is highly expressed in cancer cells as well as cancer-associated fibroblasts and has been shown to be highly expressed in sarcomas (63). This evidence concerns the gene HIF1A and sarcoma.