As to HLA − A∗26 risk allele, our real-world data are a confirmation of the results imputed by Ombrello and colleagues, who inferred in 2014 the independent role of HLA-B51 and HLA-A26 in BS susceptibility by imputed MHC-region SNPs and also found HLA − B∗15 to be an independent BS risk [48]. This evidence concerns the gene HLA-C and Bloom syndrome.