Here, for the first time, we meta-analysed the HLA class I and II genes involved in BS susceptibility in all ethnic worldwide groups, collecting HLA genetic data from 31 case-control studies and retrieved allelic frequencies for the HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1, and HLA-DPB1 genes. This evidence concerns the gene HLA-DRB1 and Bloom syndrome.