Among the top 10 hub genes, the expression level of 9 genes (CTNNB1, PTEN, KRAS, CCND2, CCKN1B, MYCN, ESR1, CCND1, and AKT1) showed statistically significant differences between the normal and stroke tissues based on the GSE58294 dataset. This evidence concerns the gene CTNNB1 and stroke disorder.