Therefore, hsa-miR-3591-5p/CTNNB1, hsa-miR-548as-3p/PTEN, hsa-miR-4503/MYCN, hsa-miR-206/ESR1, and hsa-miR-206/AKT1 can serve as potential signaling pathways regulating stroke disease. This evidence concerns the gene ESR1 and Stroke.