To further determine the role of DEMs in stroke, we used the GSE58294 database to demonstrate the expression level of the top 10 hub genes (CTNNB1, PTEN, ESR1, CCND1, KRAS, AKT1, CCND2, CDKN1B, MYCN, and VEGFA) in stroke tissues and normal tissues. The gene discussed is ESR1; the disease is Stroke.