Berberine (HL4, MOL001454, OB = 36.86%, DL = 0.78) is a small molecule derived from Coptidis rhizome, and Berberine could induce mitochondrial apoptosis and G0/G1 cell cycle arrest mediated by the PI3K-AKT signaling pathway in the thyroid carcinoma cell lines [25]. This evidence concerns the gene PIK3CG and thyroid gland carcinoma.