To screen key genes associated with DM-ILD, we extracted 35 common genes from lung disease and skin disease in DO analysis (Figure 4A), namely, BDKRB2, CAMP, COL1A1, F2RL1, F3, MS4A2, CXCR3, ICAM1, IGFBP3, IGHE, IL1A, IL1B, IL1RN, IL6, CXCL8, IL9R, IL10, IL18, CXCL10, KRT18, LAMA5, LAMC2, LEP, MET, CXCL9, MMP1, MMP2, MMP9, PLAUR, PPARG, RNASE2, RNASE3, SOD2, TLR4, and IL1RL1. Here, IL1RN is linked to interstitial lung disease.