To screen key genes associated with DM-ILD, we extracted 35 common genes from lung disease and skin disease in DO analysis (Figure 4A), namely, BDKRB2, CAMP, COL1A1, F2RL1, F3, MS4A2, CXCR3, ICAM1, IGFBP3, IGHE, IL1A, IL1B, IL1RN, IL6, CXCL8, IL9R, IL10, IL18, CXCL10, KRT18, LAMA5, LAMC2, LEP, MET, CXCL9, MMP1, MMP2, MMP9, PLAUR, PPARG, RNASE2, RNASE3, SOD2, TLR4, and IL1RL1. This evidence concerns the gene TLR4 and diabetes mellitus.