GAPDH and neoplasm: As per the fold change analysis, 89 cases out of 140 samples seemed to be downregulated (5.09-fold), while the expression pattern of FOXP3 at the level of mRNA, when normalized accordingly with the internal control GAPDH in tumor and non-tumor tissues, was 2.07 ± 0.7 (mean ± standard error) and 2.51 ± 0.4 (mean ± standard error) (Figure 1B), (p-value of <0.0001; Table 1) respectively.