Among them, NGF, TrkA (NTRK1), and Prdm12 (PRDM12) collaboratively participate in the promotion of nociceptor fate (Desiderio et al., 2019); correspondingly, pathogenic variations in these genes result in autosomal recessive conditions with similar symptoms, namely, HSAN V (MIM #608654), HSAN IV (CIPA), and HSAN VIII (MIM #616488). This evidence concerns the gene NTRK1 and hereditary sensory and autonomic neuropathy type 5.