revealed that NT5C2 mutations could lead to a severe neurodegenerative motor neuron disease, hereditary spastic paraplegia (Spastic paraplegia 45, MIM #613162) (Novarino et al., 2014), which was validated by other studies (Darvish et al., 2017; Naseer et al., 2020). The gene discussed is NT5C2; the disease is hereditary spastic paraplegia.