HLA-G and COVID-19: Although detailed information on the significance of HLA-G/receptor signalling in SARS-CoV-2 infection is lacking, the multifaceted immune suppression induced by HLA-G engagement with the aforementioned receptors has provided accumulating evidence that HLA-G/receptor signalling induces immune impairment and exhaustion, and cytokine release could be of critical importance in COVID-19.