HLA-G and COVID-19: HLA-G expression was found in intestinal mucosa epithelial cells and in some lymphocytes, in correspondence with SARS-CoV-2–positive sites. In submucosa, HLA-G expression was detectable only in few lymphocytes. Induction of HLA-G expression at the site of SARS-CoV-2 infection might be a cause of the COVID-19-dependent bleeding.