In contrast with our results in Graves’ disease patients (24), deeply analysis of this subpopulation showed an increase in percentage and counts of DP cells with a naïve phenotype (CD45RA+CCR7+CD27+; p=0.043 and p=0.008) and a decrease in percentage and counts of DP T cells with an early EM phenotype (CD45RA-CCR7-CD27+; p=0.009 and p=0.015) at the onset of T1D when compared with HD (Figure 5). This evidence concerns the gene CD27 and type 1 diabetes mellitus.