Conversely, two recent studies investigating the influence of B cell specific IFNAR KO in spontaneous SLE settings (B6.Sle1b IFNAR-/-: μMT chimeras or B6.Nba2 Mb1-Cre IFNARflx/flx mice) found a decreased GCB cell population in mice with IFNAR deficient B cells (25, 50). The gene discussed is IFNAR1; the disease is systemic lupus erythematosus.