In this study, after analysis of immune-related genes in the Cancer Genome Atlas Colon Adenocarcinoma (TCGA-COAD) dataset, we defined TNFRSF11B as an independent risk factor for the prognosis of colon cancers, which is closely related to tumor stage and lymph node metastasis. The gene discussed is TNFRSF11B; the disease is colon adenocarcinoma.