TNFRSF11B may affect the transcriptional activity of YWHAZ to regulate pathogenic E. coli infection (Figure 5I), which was further validated in the TCGA-COAD database, in which increased TNFRSF11B expression correlated with increased TWHAZ expression (cor = 0.185, p <0.001) (Figure 5J). This evidence concerns the gene YWHAZ and escherichia coli infection.