Knocking out TNFSF11 and TNFRSF11A in mice impeded the formation of secondary lymph nodes, including lymph nodes and Peyer’s patches (9), and TNFRSF11B acted as a suppressive effector in the recruitment of T cells and activation of DCs, which was supported by the results of a melanoma study that showed that in metastatic lymph nodes, melanoma cells produced large amounts of TNFRSF11B, which mediated the impairment of the interaction between T cells and DCs to dampen immune system activation (10). This evidence concerns the gene TNFRSF11B and melanoma.