A risk scoring system consisting of eight IRGs (FGFR2, ZC3HAV1L, TNFRSF11B, CD79A, IGHV3-11, IGHV3-21, IGKV2D-30, and IGKV6D-21) was constructed to evaluate the prognosis of colon cancer patients based on multivariate Cox analysis. Here, CD79A is linked to colonic neoplasm.