There is growing evidence that CCR2/CCR5 and its ligands, including MCP-1 (CCL2) and RANTES (CCL5), are involved in the pathogenesis of liver fibrosis through the promotion of monocyte/macrophage mobilization and tissue infiltration, and the activation of HSCs after liver injury (41–44). This evidence concerns the gene CCR5 and Hepatic fibrosis.