A total of 17 genetic causes of OI have been described to date, with inheritance patterns ranging from autosomal dominant (e.g. COL1A1, COL1A2, IFITM5), autosomal recessive (e.g. LEPRE1, PPIB, SERPINH1, PLOD2, BMP1, WNT1), and X-linked (PLS3). The gene discussed is PLOD2; the disease is osteogenesis imperfecta.