Mutations in any of EDA, EDAR, and EDARADD can contribute to hypohidrotic ectodermal dysplasia (HED), which affects 1 in 10,000–100,000 newborns (Wohlfart et al., 2016; Feng et al., 2018; Liu et al., 2019). Here, EDA is linked to hypohidrotic ectodermal dysplasia.