As shown in Table 1, serum insulin levels were significantly higher in T2DM mice than in normal mice (about 2-fold higher), and treatment with PEG-Loxe-L, PEG-Loxe-H, and Lira further significantly increased serum insulin levels by 12.94, 26.80, 12.24%, respectively (p < 0.05). Here, INS is linked to type 2 diabetes mellitus.