Among them, paeonol was reported to promote phagocytosis of macrophages through confining HMGB1 to the nucleus, thereby promoting the immune response during sepsis (Miao et al., 2020) and attenuate the inflammation mediated by HMGB1 and IKK-β by upregulating miR-339-5p expression, thereby protecting the kidneys and improving the survival rate of sepsis mice (Mei et al., 2019). Here, IKBKB is linked to Sepsis.