KEGG enrichments showed that the key response proteins could be involved in 189 pathways, and mainly involved in some signaling pathways of PI3K-Akt (hsa04151), MAPK (hsa04010), Rap1 (hsa04015), human cytomegalovirus infection (hsa05163), and T-cell receptor (hsa04660), etc. Many of these pathways had been reported to have close association with sepsis. The gene discussed is AKT1; the disease is cytomegalovirus infection.