Quercetin was reported to protect mice from LPS-induced sepsis by inhibiting TNF-α and IL-1β expressions, NF-κB activation, and apoptosis (Wei et al., 2018) and proposed to prevent myocardial dysfunction through the TLR4/NF-κB signaling pathway during sepsis (He et al., 2020). The gene discussed is IL1B; the disease is Sepsis.