P2RX7 and Sepsis: For example, heat shock protein 70 in the intracellular environment was reported to have chaperone activity, correcting damaged proteins and modulating inflammatory response (Sulzbacher et al., 2020); P2X7 receptor blockers were reported to limit oxidative damage and inflammations in sepsis (Larrouyet-Sarto et al., 2020); the overexpression of protein kininogen-1 (KNG1) could strengthen inflammation and oxidation in sepsis-induced acute lung injury (Hu et al., 2020).