Based on the mouse model of acute liver injury (ALI) induced by cecal ligation and perforation (CLP) and a cell model of ALI stimulated by LPS, pretreatment with ferulic acid (MOL000389) had proved to significantly reduce liver/body weight ratio, decrease the activities of MPO, AST, and ALT, and alleviate the inflammatory responses and improve CLP-induced histopathological changes in the liver. The gene discussed is MPO; the disease is acute respiratory distress syndrome.