MAPK3 and Sepsis: Among the composition of the botanical drugs in XBJI, HH played a primary role by activating blood circulation (Gong et al., 2015; Li et al., 2021) and removing blood stasis, and has been proved to mediate a pro-angiogenic role by enhancing the stability of VEGF-A and MMP-9 mRNA (Zou et al., 2018) and protecting LPS-induced cardiac fibrosis through the ERK1/2 signaling pathway while severe and potentially fatal hypotension and cardiac contractile dysfunction are treated as the common symptoms in patients with sepsis (Han et al., 2017).