CS has been reported to inhibit inflammation in experimental sepsis and RAW264.7 cells (Jiang et al., 2009; Wang et al., 2014), improve survival in LPS-challenged mice by its important ingredient, paeoniflorin (Cao et al., 2011), and prevent acute lung injury induced by LPS through the PTEN/AKT pathway in a silencing information regulator 2–related enzyme 1–dependent manner by its important ingredient, oxypaeoniflorin (Guohua et al., 2021). This evidence concerns the gene AKT1 and Sepsis.