TNF and bacterial infectious disease with sepsis: Baicalin could significantly reduce IL-1β in the sera of bacterial infected mice and could inhibit NLRP3 inflammasome activation through augmenting PKA signaling, thereby improving mouse survival in bacterial sepsis (Li et al., 2017) and could reduce the level of LPS, TNF-α, and IL-6 in the blood of sepsis mice (Chen et al., 2016).