Increasing evidence showed that phosphoinositide kinases played a momentous role in mediating viral infections (Burke, 2018), and the coumarin derivatives exhibited a tremendous inhibitory activity toward the phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt) pathways (Ma and Liu, 2017; Umar et al., 2020). Here, AKT1 is linked to viral infectious disease.