APP and Alzheimer disease: In the context of AD models, CR can decrease Aβ load in APP/PS1 mice (Mouton et al., 2009) as well as many other AD mouse models (Patel et al., 2005; Wang et al., 2005; Halagappa et al., 2007; Dhurandhar et al., 2013; Schafer et al., 2015).