NRF1 and Hypertension: Nrf1 has been reported to modulate the transcription of several genes related to antioxidant expression such as SOD1 and cytochrome c oxidase subunits (Venugopal and Jaiswal, 1996; Ohtsuji et al., 2008; Dhar et al., 2009; Zhao et al., 2011), and thus may be involved in ROS regulation during the pathophysiology of hypertension.