Our demonstration, based on in vitro and in vivo studies, of a selective increase in FSH secretion in response to CB NP exposure, potentially underlines an alteration of the reproductive function as it is observed in patients or in animal models of ovarian insufficiency (Guigon et al., 2005; Vandormael-Pournin et al., 2015; Malini and Roy George, 2018). Here, BRD2 is linked to ovarian dysfunction.