Mechanistically, we show that complete inactivation of SWI/SNF ATPase induces a rapid, near-complete and targeted loss of chromatin accessibility at the core-enhancer circuitry of AR, FOXA1, MYC and ERG, thereby attenuating their cancer-promoting transcriptional programs and tempering the enhancer-wired supra-physiologic expression of driver oncogenes (Fig. 4f). Here, MYC is linked to cancer.