CD8A and neoplasm: The primary tumor immune microenvironment of 31 baseline primary tumor samples was assessed per multiplex immunofluorescence and revealed a higher baseline median CD3 + CD8 + intratumoral T-cell density in patients with MPR (154, IQR 156) compared to patients without MPR (58, IQR 157), although this difference was not statistically significant (P = 0.31, Fig. 1g).