Pt32, who could not undergo surgery, had a baseline tumor characterized by a high CPS (40), but low TMB (80, trial median 172), low baseline IFNγ gene expression (Z-score −0.92, trial median −0.26) and low intratumoral CD8 + T-cells (41.7, trial median 83.8 cells/mm2). This evidence concerns the gene IFNG and neoplasm.