MAPT and Alzheimer disease: By initiating membrane lipid peroxidation, ROS generated by mitochondrial dysfunction may also promote the accumulation of pathological extracellular amyloid-β (Aβ) peptides and intraneuronal hyperphosphorylated tau (p-tau) protein and subsequent formation of AD-defining Aβ plaques and neurofibrillary tangles, which in turn promotes mitochondrial defects [77–79].