For example, silomus, also known as rapamycin, has been shown to prevent protein aggregation by inducing mitophagy through direct binding and inhibition of the mammalian target of rapamycin (mTOR) complex (mTORC1) and will also inhibit mTOR complex (mTORC2) activity after prolonged treatment in models of neurodegenerative disease[67–69]; however, its serious side effects, independent of autophagy, are also noteworthy. This evidence concerns the gene MTOR and neurodegenerative disease.