BNIP3 and brain infarction: In contrast, in comparison to BNIP3-WT mice, BNIP3-KO mice manifest increased autophagy, decreased apoptosis, and decreased cerebral infarction volume through inhibition of mitophagy by decreasing BNIP3 interaction with LC3, suggesting that BNIP3 gene silencingis beneficial for neuroprotection after stroke [104] (Fig. 2).The differences in these results may be related to factors, such as the constructed stroke animal model, observed post-stroke timing, and undetected autophagy flux.