Methylation in three sites was associated with incident CHD over 25 years in the WHI cohort: cg16461485 located in the body of SELT, cg02851049 located in the body of POLR3K, and cg20210586 in the body of TRIM39. None of these sites have been identified in previous EWAS. This evidence concerns the gene POLR3K and coronary artery disorder.