AKT1 and cancer: Changes in cancer signaling-associated protein levels and their activation status (phospho-signaling) can be detected by Reverse Phase Protein Array (RPPA), and the pathway-enrichment statistical scatterplot showed that TE-1 NC and TE-1-PTX differential miRNA target molecules were enriched in the PI3K-AKT signaling pathways (Fig. 5a and b) both in KYSE-150 and TE-1 cells.