CD68 and type 2 diabetes mellitus: However, CD68 expression showed a strong trend toward an increase in ipsilateral striatum of T2D/Ob mice vs. non-T2D mice (p ≈ 0.1, Fig. 3d, f) and this trend was abolished by weight loss in T2D/WL mice (p ≈ 0.1, Fig. 3d, f).