We found that a small recombinant molecule belonging to the F. hepatica fatty acid binding protein (Fh15) administered intravenously in rhesus macaques prior to an infusion with lethal amounts of live E. coli (i) significantly reduces bacteremia and subsequently suppresses the levels of LPS in plasma and reduces the production of CRP and PCT, which are key signatures of inflammation and bacterial infection, respectively; (ii) notably reduced the production of proinflammatory cytokines and chemokines; and (iii) prevented the immune cell disappearance from the bloodstream. The gene discussed is CRP; the disease is bacterial infectious disease with sepsis.