IFNA1 and COVID-19: We next examined differential gene expression patterns in healthy versus COVID-19 samples, followed by Gene Ontology term enrichment, in cell types that are particularly associated with disease: transit epithelial 1 and goblet 2 inflammatory cells upregulated in adult COVID-19, and IL-6 monocytes upregulated in children, as strong IFNα responders (Fig. 2f).