KLK4 and Familial prostate cancer: We observed an increase in cholesterol homeostasis pathway genes (Hallmarks, Figure S8C) and linoleic acid (a fatty acid) metabolism pathway genes (KEGG, Figure 6D) in prostate cancer–associated LE-KLK4 cells, raising the possibility that the fatty acid response gene enrichment in MAC-MT cells may arise due to fatty acid generation by local LE-KLK4 cells.