High expression of metallothioneins has been noted in prostate cancer (Wei et al., 2008, Wang et al., 2018), but the MAC-MT cluster contained cells from both our dataset and that generated from normal, young human prostate tissue (Henry et al., 2018; Figure S4C), confirming that these cells exist in healthy prostate tissue in homeostasis. Here, MCAT is linked to Familial prostate cancer.