The effects of MAC-MT enrichment are in contrast to previous studies investigating MNPs in prostate cancer which have associated the presence of myeloid-derived suppressor cells (Brusa et al., 2013) and CD163-positive M2 macrophages (Erlandsson et al., 2019) with worse survival, and emphasize the value of scRNA seq in delineating distinct cell subsets with important transcriptional and functional differences (Montoro et al., 2018). Here, CD163 is linked to prostate carcinoma.