Previous studies have reported that METTL1 modulates the miR‐149‐3p/S100A4/p53 axis, let‐7e miRNA/HMGA2 axis, and the PTEN pathway in colon cancer as well as hepatocellular carcinoma.20, 25, 42. The gene discussed is HMGA2; the disease is malignant colon neoplasm.