LAMP1 and Huntington disease: The increase in autophagosomes was coupled to an increased number and size of p62 puncta in neurites as well as an increase in the number and size of LAMP1-positive puncta at this same location (Fig. 3E–H), indicating that autophagosomes and autophagolysosomes remain in the neurites and fail to transport their cargo to the soma for degradation in HD-iNs.