Each of these proteins of interest showed substantial increased mRNA expression by DEseq in the tumor cells from tumors from Dicer1fl/fl/Pf4-Cre mice compared to Pf4-Cre mice: Tenascin C (log(2) fold change 1.83 [3.55-fold increase], padj 1.22 x 10−11), Mucin 4 (log(2) fold change 1.69 [3.22-fold increase], padj 2.76 x 10−5), and Cadherin 17 (log(2) fold change 1.24 [2.36-fold increase], padj 0.0016) (S1 Table). This evidence concerns the gene PF4 and neoplasm.