PF4 and neoplasm: As further evaluation of direct platelet miRNA effects on the tumor cell transcriptome, we performed miRNA target prediction analysis for the 548 increased mRNAs using miRNet (mirnet.ca), followed by filtering for the 44 most depleted miRNAs we previously identified in platelets from Dicer1fl/fl/Pf4-Cre mice compared to controls [52].