INS and type 2 diabetes mellitus: Non-pharmacological or conventional treatment of T2DM involves the use of dietary interventions and physical activity [10], whereas pharmacological treatment consists of the use of drugs such as sulfonylurea (in normal-weight individuals) and metformin (in overweight and obese patients), or insulin when diabetes is first detected and the blood glucose is very high, or when a patient’s blood glucose levels remain persistently high [11].