MLH1 and neoplasm: Consequently, MLH1 hypermethylation was significantly associated with tumor location (P = 0.0298), morphological type (P = 0.0155), depth of invasion (P = 0.0233), lymph node metastasis (P = 0.0208), pathological stage (P = 0.0253), and histological type (P = 0.0024).