In curative surgery, gastric cancer with MLH1 hypermethylation had 7 recurrences (1 liver, 1 lung, 2 bone, 1 brain, 1 adrenal gland, 1 peritoneum, in which less peritoneal dissemination was seen than in MLH1 hypomethylation cases). This evidence concerns the gene MLH1 and gastric cancer.