PTPN11 and psoriasis: To determine the causal role of SHP2 in psoriasis, we generated myeloid cell lineages (monocytes, mature macrophages, and granulocytes)‐specific SHP2 conditional knockout mice, called M‐Shp2−/− mice (Lyz2‐cre:Shp2fl/fl mice), and confirmed a pretty efficiency of Shp2 deletion in bone marrow‐derived macrophages (BMDMs), but not in bone marrow‐derived dendritic cells (BMDCs), as shown in Appendix Fig S10A.