From the clinical level of psoriasis patients, the whole animal level, and the cellular level, this study reveals that SHP2 promotes TLR7 trafficking to endosomes and activates the downstream NF‐κB pathway through dephosphorylation of TLR7, thus exacerbating the pathogenesis of psoriasis and providing a potential target for the development of therapeutic drugs for psoriasis. Here, PTPN11 is linked to psoriasis.