In this study, we first proved that TLR7 can be phosphorylated at Tyr1024 in the skin lesions of psoriatic patients and that its dephosphorylation by SHP2 accelerates TLR7 ubiquitination and promotes TLR7 activation of NF‐κB signaling, contributing to the aggravation of psoriasis. The gene discussed is NFKB1; the disease is psoriasis.