By dephosphorylating TLR7 at Tyr1024 and inducing TLR7 ubiquitination, SHP2 drove the trafficking of TLR7 to the endosomes, which sustained the activation of downstream TLR7/NF‐κB signaling, thereby promoting the development of psoriasis (Fig 9F). Here, PTPN11 is linked to psoriasis.