PRKAA2 and myocardial ischemia: Heart is an organ with a high energy demand, whose function depends on mitochondria and adenosine triphosphate (ATP).7 Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK), a heterotrimeric, as a sensor of energy metabolism, plays an essential role in the regulation of cardiac ischemia and reperfusion.8 AMPK has been reported to inhibit ferroptosis through energy stress.9 So, whether AMPK exerts a protective effect on myocardial I/R injury is the focus of our study.