For example, mTOR is a serine/threonine protein kinase that plays a pivotal role in regulating proteostasis in cardiomyocytes (10–12); partial mTOR inhibition through either pharmacological or genetic approaches exerts cardioprotective effects on several types of cardiomyopathies, including lamp2-associated HCM (13), bag3-associated and lamin A/C-associated DCM (14, 15), and anemia- and doxorubicin-induced cardiomyopathies (DICs) (16). Here, BAG3 is linked to cardiomyopathy.