Therapeutic effects similar to mtor inhibition have been observed on several other CM models, including anemia-induced CM (16), anthracycline-induced cardiotoxicity (16), bag3-associated DCM (14), and lamp2-associated HCM (13), suggesting that mtor signaling is a common pathological event in these CMs with distinct etiologies. The gene discussed is BAG3; the disease is anemia (phenotype).