Mitochondrial functions including oxidative phosphorylation, nuclear factor erythroid-2 related factor 2–mediated (NRF2-mediated) oxidative stress response, senescence, and sirtuin signaling pathways were among those most enriched in our whole-cell proteome data set during hyperammonemia and following withdrawal (Figure 1D). Here, NFE2L2 is linked to Hyperammonemia.