This study also found that alcohol consumption, degree of differentiation, depth of infiltration, lymph node metastasis, clinical stage, and Fn-induced CD8+T cells with high expression of KIR2DL1 were independent risk factors affecting the prognosis of ESCC patients, and the 5-year survival rate and median survival time of patients in the positive group were significantly lower than those in the negative group. Here, KIR2DL1 is linked to esophageal squamous cell carcinoma.