Thus, it is conceivable that the up‐regulation of circulating levels of GIP in Lep‐treated TDP‐43A315T mice would help to reduce disturbances in energy metabolism associated with the progression of ALS in TDP‐43A315T mice (Shan et al., 2010; Wang et al., 2013). Here, LEP is linked to amyotrophic lateral sclerosis.