LEP and amyotrophic lateral sclerosis: We next studied how metabolic markers in plasma were affected by leptin treatment in TDP‐43A315T mice compared to age‐matched WT littermates, as metabolic homeostasis is unbalanced in ALS patients (Ioannides et al., 2016), and this hormone is historically known for its important role in regulating body weight (Friedman, 2011).