The incidence of grade 3–5 irAEs was 5.8% (110/1905), with the most common grades 3–5 irAEs being pneumonitis (1.8%, 35/1905), followed by dermatological toxicities (1.2%, 22/1905) and increased alanine aminotransferase (ALT, 0.8%, 16/1905). This evidence concerns the gene GPT and pneumonitis.