Patients with PHP1A manifest multi-hormone resistance (e.g., resistance to TSH, LH/FSH, GHRH), obesity and features of AHO, which include short stature, brachydactyly, subcutaneous calcification, and round facies.4,5 In contrast, PHP1B patients do not typically have multi-hormone resistance or AHO. This evidence concerns the gene BRD2 and pseudohypoparathyroidism type 1A.