The previously reported AD-associated rare COBL, AKAP9, and TREM2 variants in African Americans [86–89] were replicated in this larger GWAS as follows: COBL/rs112404845 (200 kb upstream of COBL) at p = 5.4E − 06, AKAP9/rs149979685 (p.Ser3771Leu) at p = 0.005, AKAP9/rs914662445 (p.Ile2558Met) at p = 0.01, TREM2/rs2234256 (p.Leu211Pro) at p = 0.001, TREM2/rs2234258 (p.Trp191X) at p = 1.4E − 03, and TREM2/rs7748513 at p = 3.6E − 05. The gene discussed is TREM2; the disease is Alzheimer disease.