SPPL2A and Alzheimer disease: A recent such study has integrated AD GWAS with multiple peripheral myeloid genomic datasets [125], which nominated multiple candidate genes: BIN1, SP1, ZYX, EPHA1, MS4A6A, MS4A4A, PILRA, RABEP1, SCIMP, PTK2B, GPR141, SPPL2A, and CD2AP. Noteworthy, the EPHA1/EPHA1-AS1 association signal is an eQTL for the EPHA1-AS1 noncoding RNA both in primary microglia and in IPSDMac [123], suggesting that the AD risk may be mediated by EPHA1-AS1 expression levels.