This first large-scale WES from ADSP [103] confirmed associations with common and rare variants in multiple previously established AD genes, including APOE, ABCA7, HLA-DPA1, MS4A6A, PILRA, SORL1, and TREM2. This study also identified three novel genes: one rare exome-wide significant variant in a long non-coding RNA gene, AC099552.4 (p = 1.2E − 07) on chromosome 7; one common nearly exome-wide significant variant in IGHG3 (p = 9.8E − 07) on chromosome 14; and a gene-wide significant association with ZNF655, including 9 high-impact rare variants (p = 5E − 06) on chromosome 7. This evidence concerns the gene SORL1 and Alzheimer disease.