CLU and early-onset autosomal dominant Alzheimer disease: The combined sample in the first study, which was derived from a collaborative consortium Genetic and Environmental Risk in Alzheimer’s Disease (GERAD) from Europe and the USA, was 16,152 subjects (5964 cases, 10,188 controls) from the discovery and replication stages and identified the CLU (also known as APOJ) and PICALM loci [60].