The second study used a 2-stage study consisting of 22,771 subjects (11,840 cases, 10,931 controls) derived from 12 cohorts and the U.S. National Institute on Aging (NIA)–funded Alzheimer Disease Centers, as part of the Alzheimer Disease Genetics Consortium (ADGC), and identified the MS4A4/MS4A6E and EPHA1 loci. This evidence concerns the gene EPHA1 and Alzheimer disease.