Conditional analyses done on AD-associated variants in three recent large GWAS meta-analyses [73–75] identified at least two independent signals in 10 loci (BIN1, PKT2B/CLU, ABCA7, NCK2, EPHA1, ADAM10, ACE, APP/ADAMTS1, TREM2, and APOE), suggesting that there may be at least 10 additional loci which are not included in the currently known approximately 95 loci. The gene discussed is APOE; the disease is Alzheimer disease.