Conditional analyses done on AD-associated variants in three recent large GWAS meta-analyses [73–75] identified at least two independent signals in 10 loci (BIN1, PKT2B/CLU, ABCA7, NCK2, EPHA1, ADAM10, ACE, APP/ADAMTS1, TREM2, and APOE), suggesting that there may be at least 10 additional loci which are not included in the currently known approximately 95 loci. This evidence concerns the gene APP and Alzheimer disease.