BIN1 and Alzheimer disease: Another novel locus, BIN1, was identified in 2010 in a three-stage analysis of new and previously published GWAS on 35,336 subjects (8371 cases, 26,965 controls) derived from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, Translational Genomics Research Institute (TGEN), Mayo AD GWAS, EADI, and GERAD consortium [62].