Models combining these biomarkers, weighted by their effect sizes in the mutually adjusted models, and adjusted for BMI, lifetime alcohol consumption, smoking, physical activity level, educational level, baseline self-reported diabetes, and baseline self-reported hypertension, showed moderately strong associations with cancer and CVD risk, ranging from HRQ4-Q1 = 1.78 [1.36, 2.34] for breast cancer (combining NT-proBNP and HbA1C), to HRQ4-Q1 = 2.87 [2.15, 3.83] for MI (combining NT-proBNP, HbA1C, CRP and cystatin-C) (Table 4). The gene discussed is CST3; the disease is hypertensive disorder.