By contrast, the only biomarkers associated with breast cancer risk were NT-proBNP and HbA1C, whereas only GDF-15 (negative) and NT-proBNP (positive) were associated with prostate cancer, only GDF-15 and HbA1C with lung cancer risk, and only NT-proBNP with colorectal cancer risk. The gene discussed is NPPB; the disease is Familial prostate cancer.