With regard to cancer, basic risk models adjusted only for age and sex showed increased risks at multiple cancer (organ) sites for higher blood concentrations of NT-proBNP (breast, prostate, colorectum), HbA1C (lung, colorectum, breast), and CRP (lung, colorectum), whereas higher GDF-15 levels were associated only with an increased risk of lung cancer. The gene discussed is GDF15; the disease is lung cancer.