Importantly, we observed that wild-type FGFR3 tumours in the UROMOL validation cohort were significantly associated with a higher RNA-derived immune infiltration score (n = 129; Wilcoxon rank sum test, p = 0.003; Fig. 3H), indicating a tumour microenvironment with an immune system supportive of response. The gene discussed is FGFR3; the disease is neoplasm.