Of the 335 patients with DM who failed to achieve target HbA1c at 1 year (45.0%), 14 (1.9%) had type 1 diabetes, 202 (27.1%) type 2 diabetes (non–insulin-dependent), and 119 (16%) had type 2 diabetes (insulin-dependent) (Figure 4A). This evidence concerns the gene INS and type 2 diabetes mellitus.